Understanding How Disease and Environment Combine to Structure Resistance in Estuarine Bivalve Populations

Delaware Bay oyster (Crassostrea virginica) populations are influenced by two lethal parasites that cause Dermo and MSX diseases. As part of the US National Science Foundation Ecology of Infectious Diseases initiative, a program developed for Delaware Bay focuses on understanding how oyster population genetics and population dynamics interact with the environment and these parasites to structure he host populations, and how these interactions might modified by climate change. Laboratory and field studies undertaken during this program include identifying genes related to MSX and Dermo disease resistance, potential regions for refugia and the mechanisms that allow them to exist, phenotypic and genotypic differences in oysters from putative refugia and high-disease areas, and spatial and temporal variability in the effective size of the spawning populations. Resulting data provide inputs to oyster genetics, population dynamics, and larval growth models that interface with a three-dimensional circulation model developed for Delaware Bay. Reconstruction of Lagrangian particle tracks is used to infer transport pathways of oyster larvae and MSX and Dermo disease pathogens. Results emerging from laboratory, field, and modeling studies are providing an understanding of long-term changes in Delaware Bay oyster populations that occur as the oyster population responds to climate, environmental, and biological variability

Gapless surface Dirac cone in antiferromagnetic topological insulator MnBi2_2Te4_4

The recent discovered antiferromagnetic topological insulators in Mn-Bi-Te family with intrinsic magnetic ordering have rapidly drawn broad interest since its cleaved surface state is believed to be gapped, hosting the unprecedented axion states with half-integer quantum Hall effect. Here, however, we show unambiguously by using high-resolution angle-resolved photoemission spectroscopy that a gapless Dirac cone at the (0001) surface of MnBi$_2$Te$_4$ exists between the bulk band gap. Such unexpected surface state remains unchanged across the bulk N\'eel temperature, and is even robust against severe surface degradation, indicating additional topological protection. Through symmetry analysis and $\textit{ab}$-$\textit{initio}$ calculations we consider different types of surface reconstruction of the magnetic moments as possible origins giving rise to such linear dispersion. Our results reveal that the intrinsic magnetic topological insulator hosts a rich platform to realize various topological phases such as topological crystalline insulator and time-reversal-preserved topological insulator, by tuning the magnetic configurations.Comment: 9 pages, 4 figures. To appear in Phys. Rev. X. See Version 1 for the supplementary fil

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Experimental Study on Axial Temperature Profile of Jet Fire of Oil-Filled Equipment in Substation

With the widespread use of substations around the world, oil jet fire accidents from transformer oil-filled equipment in substations caused by faults have occurred from time to time. In this paper, a series of transformer oil jet fire experiments are carried out by changing the external heat source (30 cm and 40 cm) and the inner diameter of the container (5 cm, 8 cm and 10 cm) to study the axial centerline temperature distribution of the transformer oil jet fire plume of the transformer oil-filled equipment in the substation. The experiment uses K-type thermocouple, electronic balance and CCD to measure and assess the temperature distribution of the axial centerline of the fire plume of the transformer oil jet. The result demonstrates that the axial centerline temperature of the fire plume increases with the external heat release rate and the inner diameter of the container. In addition, a novel axial temperature distribution prediction model of the transformer oil jet fire plume is established. This model can effectively predict the oil jet fire plume temperature of transformer oil- filling equipment in substations, and provide help for substation fire control

DEM Parameter Calibration of Maize Seeds and the Effect of Rolling Friction

A set of suitable parameter values is crucial in discrete element method (DEM) simulations. As a non-spherical particle, the coefficients of rolling friction between maize seed particles and between the seed particles and the boundary are hard to measure directly and must be obtained by calibration. In this paper, taking three representative maize varieties as research objects, the necessity for the accurate calibration of the coefficients of rolling friction between seed particles and between seed particles and boundaries is investigated. Subsequently, by studying the sensitivity of the coefficients of rolling friction between seed particles and between seed particles and the boundary to the angle of repose test, the methods used to calibrate the coefficients of rolling friction between seed particles and between the particles and the boundary are determined. It can be seen from the results that the coefficients of rolling friction between the seed particles and between the seed particles and the boundary have a significant influence on the test results, so these two parameters must be accurately calibrated. Additionally, the coefficient of rolling friction between seed particles and the boundary has no effect on the piling angle, but the piling angle is highly sensitive to the coefficient of rolling friction between seed particles. By comparing the simulation results and the experimental results in the lifting cylinder and “self-flow screening” tests, the calibrated seed parameters were found to be accurate and valid